321% faster than conventional products of gelatin.

Collagen fleeces demonstrates a significantly higher effectiveness as gelatin or cellulose sponges. In addition, they are rapidly and completely absorbed by the body and promotes granulation and epithelialization of the natural collagen.

Resorbable collagen are used to dress oral wounds, for closure of graft and extraction sites, and to promote healing. Collagen based products also have been used in periodontal and implant therapy as barriers to prevent epithelial migration and allow cells with regenerative capacity to repopulate the defect area. Clinical studies showed that epithelial growth and neo-vascularization are very important in order to avoid most critical problems in the healing periods. (Sahota et al., 2003, Sahota et al. In 2004, Schultz et. al., 2003). The usage of porcine collagen is able to establish a significant higher rate of new epithelial thickness and neo-vascularization and enables collagen fleeces like SinossFleece to become a matrix for tissue-engineering.





SinossFleece Zeit D

SinossFleece supports the formation of soft tissue and can be used as a carrier
material in tissue engineering

SinossFleece is a resorbable, volume stable collagen matrix of porcine origin and was specially developed for soft tissue regeneration. The collagen matrix consists of native collagen, is not cross-linked and retains the high volume stability even when wet. And that with very good biocompatibility to support angiogenesis, the new formation of connective tissue with submerged healing. SinossFleece is thus an alternative to autologous connective tissue grafts (BGT) within regenerative soft tissue surgery to avoid an additional donor site and reduce patient morbidity. While many collagen matrices only have an insufficient dimensional stability due to the absorption of fluid have a shrinkage of 20-30% and higher. SinossFleece remains the targeted geometrically determined volume.The shrinking process of conventional collagen matrices resulting in significantly reduced three-dimensionality of and leads to a loss or significant restriction of the characteristics of cell proliferation and cell differentiation. The dimensionally stable SinossFleece not only fulfills a carrier function but as a construct also promotes a three-dimensional growth in the defect and is suitable to replace the body's own tissues.






* Use of a porcine collagen matrix as an alternative to autogenous tissue for grafting oral soft tissue defects.

Herford AS, Akin L, Cicciu M, Maiorana C, Boyne PJ.; SourceDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Loma Linda University Medical Center, Loma Linda, CA 92350, USA; J Oral Maxillofac Surg. 2010 Jul;68(7):1463-70. Epub 2010 Apr 22.; (Abstract)

PURPOSE: Soft tissue grafting is often required to correct intraoral mucosal deficiencies. Autogenous grafts have disadvantages including an additional harvest site with its associated pain and morbidity and, sometimes, poor quality and limited amount of the graft. Porcine collagen matrices have the potential to be helpful for grafting of
soft tissue defects.

PATIENTS AND METHODS: Thirty consecutive patients underwent intraoral grafting to re-create missing soft tissue. Defects ranged in size from 50 to 900 mm(2). Porcine collagen matrices were used to reconstruct missing tissue. Indications included preprosthetic (22), followed by tumor removal (5), trauma (2), and release of cheek
ankylosis (1).

RESULTS: The primary efficacy parameters evaluated were the degree of lateral and/or alveolar extension and the evaluation of re-epithelialization and shrinkage of the grafted area. Overall, the percentage of shrinkage of the graft was 14% (range, 5%-20%). The amount of soft tissue extension averaged 3.4 mm (range, 2-10 mm). The secondary efficacy parameters included hemostatic effect, pain evaluation, pain and discomfort, and clinical evaluation of the grafted site. All patients reported minimal pain and swelling associated with the grafted area. No infections were noted.

CONCLUSION: This porcine collagen matrix provides a biocompatible surgical material as an alternative to an autogenous transplant, thus obviating the need to harvest soft tissue autogenous grafts from other areas of the oral cavity.

































































































































































































































































































































































































































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